Four childhood friends are going through a midlife crisis so they decide to remake their favorite horror movie from the 1990s in the Amazon. When a real giant anaconda shows up, they get more than what they bargain for and their comically chaotic movie making turns into a life-or-death situation. The movie that they're dying to remake? It might just kill them, literally.

Jake and Neytiri's family grapples with grief after Neteyam's death, encountering a new, aggressive Na'vi tribe, the Ash People, who are led by the fiery Varang, as the conflict on Pandora escalates and a new moral focus emerges.