As Spike is inducted into Jimmy Crystal's gang on the mainland, Dr. Kelson makes a discovery that could alter the world.

An employee and her insufferable boss become stranded on a deserted island, the only survivors of a plane crash. Here, they must overcome past grievances and work together to survive, will they make it out alive?

After the events of the first film, Nick and Judy will discover birds, reptiles, amphibians, primates, pets, hybrid animals, and marine animals, far away from the mammal city. However, Mayor Lionheart has opened a tame collar store for these creatures.